IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2(+) cancer stem cells

We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis. The pathways regulating GD2 expression, and their anomalous functions in BCSC, are unclear....

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Detalles Bibliográficos
Autores principales: Battula, Venkata Lokesh, Nguyen, Khoa, Sun, Jeff, Pitner, Mary Kathryn, Yuan, Bin, Bartholomeusz, Chandra, Hail, Numsen, Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514883/
https://www.ncbi.nlm.nih.gov/pubmed/28415808
http://dx.doi.org/10.18632/oncotarget.16294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514883/
https://www.ncbi.nlm.nih.gov/pubmed/28415808
http://dx.doi.org/10.18632/oncotarget.16294

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