Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma

Malignant gliomas display high levels of the transcription factor c-myc and organize a tumor specific chaperone network within mitochondria. Here, we show that c-myc along with mitochondrial chaperone inhibition displays massive tumor cell death. Inhibition of mitochondrial matrix chaperones and c-m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishida, Chiaki Tsuge, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Altieri, Dario C., Karpel-Massler, Georg, Siegelin, Markus David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514897/
https://www.ncbi.nlm.nih.gov/pubmed/28415755
http://dx.doi.org/10.18632/oncotarget.16202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514897/
https://www.ncbi.nlm.nih.gov/pubmed/28415755
http://dx.doi.org/10.18632/oncotarget.16202

Ejemplares similares