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Functional and therapeutic significance of EZH2 in urological cancers

The enhancer of zeste homolog 2 (EZH2) is a core subunit of the polycomb repressor complex 2 (PRC2), which is overexpressed in numerous cancers and mutated in several others. Notably, EZH2 acts not only a critical epigenetic repressor through its role in histone methylation, it is also an activator...

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Detalles Bibliográficos
Autores principales: Liu, Xiaobing, Wu, Qingjian, Li, Longkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514970/
https://www.ncbi.nlm.nih.gov/pubmed/28410242
http://dx.doi.org/10.18632/oncotarget.16765