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Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth

BACKGROUND: We sought to address whether CF macrophages have a primary functional defect as a consequence of CFTR loss and thus contribute to the onset of infection and inflammation observed in CF lung disease. METHODS: Monocyte derived macrophages (MDMs) were prepared from newborn CF and non-CF pig...

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Detalles Bibliográficos
Autores principales: Paemka, Lily, McCullagh, Brian N., Abou Alaiwa, Mahmoud H., Stoltz, David A., Dong, Qian, Randak, Christoph O., Gray, Robert D., McCray, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515361/
https://www.ncbi.nlm.nih.gov/pubmed/28377087
http://dx.doi.org/10.1016/j.jcf.2017.03.007