Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog

A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function mechanisms have been proposed to underlie this disease, but the pathogenic pathways are n...

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Detalles Bibliográficos
Autores principales: Langseth, Abraham J., Kim, Juhyun, Ugolino, Janet E., Shah, Yajas, Hwang, Ho-Yon, Wang, Jiou, Bergles, Dwight E., Brown, Solange P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515847/
https://www.ncbi.nlm.nih.gov/pubmed/28720882
http://dx.doi.org/10.1038/s41598-017-05864-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515847/
https://www.ncbi.nlm.nih.gov/pubmed/28720882
http://dx.doi.org/10.1038/s41598-017-05864-2

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