Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol

10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of F18 in vitro and in vivo. The metabolites of F18 w...

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Detalles Bibliográficos
Autores principales: Wu, Xiangmeng, Zhang, Qinghao, Guo, Jiamei, Jia, Yufei, Zhang, Ziqian, Zhao, Manman, Yang, Yakun, Wang, Baolian, Hu, Jinping, Sheng, Li, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515859/
https://www.ncbi.nlm.nih.gov/pubmed/28769808
http://dx.doi.org/10.3389/fphar.2017.00479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515859/
https://www.ncbi.nlm.nih.gov/pubmed/28769808
http://dx.doi.org/10.3389/fphar.2017.00479

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