Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells

Impaired clearance of Amyloid β (Aβ) by microglia in the brain may be associated with the senile plaque formation, a pathological hallmark relevant to Alzheimer's disease. Microglial cells in the brain are not able to efficiently degrade Aβ, suggesting that microglial lysosome impairment may oc...

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Detalles Bibliográficos
Autores principales: Guo, Xingzhi, Tang, Peng, Chen, Li, Liu, Peng, Hou, Chen, Zhang, Xin, Liu, Yue, Chong, Li, Li, Xiaoqing, Li, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515861/
https://www.ncbi.nlm.nih.gov/pubmed/28769785
http://dx.doi.org/10.3389/fnagi.2017.00228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515861/
https://www.ncbi.nlm.nih.gov/pubmed/28769785
http://dx.doi.org/10.3389/fnagi.2017.00228

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