Cargando…

Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells

Impaired clearance of Amyloid β (Aβ) by microglia in the brain may be associated with the senile plaque formation, a pathological hallmark relevant to Alzheimer's disease. Microglial cells in the brain are not able to efficiently degrade Aβ, suggesting that microglial lysosome impairment may oc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Xingzhi, Tang, Peng, Chen, Li, Liu, Peng, Hou, Chen, Zhang, Xin, Liu, Yue, Chong, Li, Li, Xiaoqing, Li, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515861/ https://www.ncbi.nlm.nih.gov/pubmed/28769785 http://dx.doi.org/10.3389/fnagi.2017.00228

Ejemplares similares

Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy
por: Wang, Shujun, et al.
Publicado: (2022)

Role of Transcription Factor EB in Mitochondrial Dysfunction of Cisplatin-Induced Acute Kidney Injury
por: Wang, Shujun, et al.
Publicado: (2023)

Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity
por: Pi, Huifeng, et al.
Publicado: (2017)

The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
por: Zhu, Sheng-yu, et al.
Publicado: (2021)

An “Amyloid‐β Cleaner” for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction
por: Liu, Ruiyuan, et al.
Publicado: (2019)

Suppression of lysosomal acid alpha‐glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer
por: Hamura, Ryoga, et al.
Publicado: (2021)

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy
por: Kleinecke, Sandra, et al.
Publicado: (2017)

Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction
por: Tripathi, Ashutosh, et al.
Publicado: (2019)

Expression of transcriptional factor EB (TFEB) in differentiating spermatogonia potentially promotes cell migration in mouse seminiferous epithelium
por: Liu, Yue, et al.
Publicado: (2018)

Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway
por: Xu, Jie, et al.
Publicado: (2020)

Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly
por: Kim, Ki-Ryeong, et al.
Publicado: (2022)

Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model
por: Mathur, Pallavi, et al.
Publicado: (2023)

Transcription factor EB regulates cardiovascular homeostasis
por: Lu, Haocheng, et al.
Publicado: (2021)

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease
por: Prakash, Priya, et al.
Publicado: (2023)

Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway
por: Leow, San Min, et al.
Publicado: (2016)

Integrated Microbiome and Host Transcriptome Profiles Link Parkinson’s Disease to Blautia Genus: Evidence From Feces, Blood, and Brain
por: Guo, Xingzhi, et al.
Publicado: (2022)

Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
por: Durairajan, Siva Sundara Kumar, et al.
Publicado: (2013)

Correlation between Serum RANTES Levels and the Severity of Parkinson's Disease
por: Tang, Peng, et al.
Publicado: (2014)

N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction
por: Tripathi, Ashutosh, et al.
Publicado: (2020)

Impaired pulmonary function mediates the impact of preterm birth on later-life stroke: a 2-step, multivariable Mendelian randomization study
por: Guo, Xingzhi, et al.
Publicado: (2023)

PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle
por: Spaulding, Hannah R., et al.
Publicado: (2020)

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD
por: Wu, Yanwei, et al.
Publicado: (2021)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
por: Lin, Geng, et al.
Publicado: (2020)

Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1
por: Sheets, Kristopher G., et al.
Publicado: (2013)

Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes
por: Kang, Yingli, et al.
Publicado: (2019)

Lysosomal Ca(2+) Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells
por: Tseng, Hisa Hui Ling, et al.
Publicado: (2017)

Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation
por: Yu, Fengxiang, et al.
Publicado: (2015)

Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis
por: Yu, Hao, et al.
Publicado: (2022)

STUDIES ON LYSOSOMES : XII. Redistribution of Acid Hydrolases in Human Lymphocytes Stimulated by Phytohemagglutinin
por: Hirschhorn, Rochelle, et al.
Publicado: (1968)

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging
por: Geng, Li, et al.
Publicado: (2020)

Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer
por: Liu, Wei, et al.
Publicado: (2021)

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models
por: Song, Ju‐Xian, et al.
Publicado: (2019)

Tubastatin A Improves Post‐Resuscitation Myocardial Dysfunction by Inhibiting NLRP3‐Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling
por: Xu, Jiefeng, et al.
Publicado: (2022)

The causal association between iron status and the risk of autism: A Mendelian randomization study
por: Chen, Li, et al.
Publicado: (2022)

Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation
por: Chen, Yuanhan, et al.
Publicado: (2018)

Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury
por: Liu, Wei, et al.
Publicado: (2019)

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
por: Zhang, Dan, et al.
Publicado: (2011)

The Oncogene Transcription Factor EB Regulates Vascular Functions
por: Doronzo, Gabriella, et al.
Publicado: (2021)

Transcriptional and epigenetic decoding of the microglial aging process
por: Li, Xiaoyu, et al.
Publicado: (2023)

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
por: Polito, Vinicia A, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ceej01o9dj83s63gcjv7h4ubp1