Prolyl-hydroxylase inhibition induces SDF-1 associated with increased CXCR4+/CD11b+ subpopulations and cardiac repair

ABSTRACT: SDF-1/CXCR4 activation facilitates myocardial repair. Therefore, we aimed to activate the HIF-1α target genes SDF-1 and CXCR4 by dimethyloxalylglycine (DMOG)-induced prolyl-hydroxylase (PH) inhibition to augment CXCR4+ cell recruitment and myocardial repair. SDF-1 and CXCR4 expression was...

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Detalles Bibliográficos
Autores principales: Ghadge, Santhosh Kumar, Messner, Moritz, Van Pham, Thi, Doppelhammer, Maximilian, Petry, Andreas, Görlach, Agnes, Husse, Britta, Franz, Wolfgang-Michael, Zaruba, Marc-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516048/
https://www.ncbi.nlm.nih.gov/pubmed/28550361
http://dx.doi.org/10.1007/s00109-017-1543-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516048/
https://www.ncbi.nlm.nih.gov/pubmed/28550361
http://dx.doi.org/10.1007/s00109-017-1543-3

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