Cargando…

Prolyl-hydroxylase inhibition induces SDF-1 associated with increased CXCR4+/CD11b+ subpopulations and cardiac repair

ABSTRACT: SDF-1/CXCR4 activation facilitates myocardial repair. Therefore, we aimed to activate the HIF-1α target genes SDF-1 and CXCR4 by dimethyloxalylglycine (DMOG)-induced prolyl-hydroxylase (PH) inhibition to augment CXCR4+ cell recruitment and myocardial repair. SDF-1 and CXCR4 expression was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghadge, Santhosh Kumar, Messner, Moritz, Van Pham, Thi, Doppelhammer, Maximilian, Petry, Andreas, Görlach, Agnes, Husse, Britta, Franz, Wolfgang-Michael, Zaruba, Marc-Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516048/ https://www.ncbi.nlm.nih.gov/pubmed/28550361 http://dx.doi.org/10.1007/s00109-017-1543-3

Ejemplares similares

High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA
por: Messner, Moritz, et al.
Publicado: (2019)

Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy
por: Messner, Moritz, et al.
Publicado: (2018)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
por: Messner, Moritz, et al.
Publicado: (2020)

Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy
por: Ghadge, Santhosh Kumar, et al.
Publicado: (2021)

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
por: Figg, William D., et al.
Publicado: (2021)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

Function and expression of prolyl hydroxylase 3 in cancers
por: Liu, Qiu-long, et al.
Publicado: (2013)

Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2015)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
por: Strowitzki, Moritz J., et al.
Publicado: (2021)

Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
por: Harnoss, Jonathan Michael, et al.
Publicado: (2015)

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase
por: Longbotham, James E., et al.
Publicado: (2015)

Role of prolyl hydroxylase domain proteins in bone metabolism
por: Wolf, David, et al.
Publicado: (2022)

CXCL12/SDF-1 and CXCR4
por: Nagasawa, Takashi
Publicado: (2015)

Author Correction: Crosstalk between SDF-1/CXCR4 and SDF-1/CXCR7 in cardiac stem cell migration
por: Chen, Dong, et al.
Publicado: (2022)

Eosinophilic myocarditis complicated by permanent atrioventricular nodal block: a case report
por: Messner, Moritz, et al.
Publicado: (2022)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
por: Holt-Martyn, James P., et al.
Publicado: (2019)

Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis
por: Kowalski, Kamil, et al.
Publicado: (2016)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
por: Kennel, Kilian B., et al.
Publicado: (2022)

Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
por: Kant, Ravi, et al.
Publicado: (2013)

The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma
por: Hatzimichael, E, et al.
Publicado: (2012)

Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein
por: Place, Trenton L, et al.
Publicado: (2013)

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion
por: Huang, Mei, et al.
Publicado: (2016)

Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
por: Yang, Ming, et al.
Publicado: (2014)

Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase
por: Yum, Soohwan, et al.
Publicado: (2017)

An Arabidopsis Prolyl 4 Hydroxylase Is Involved in the Low Oxygen Response
por: Konkina, Anna, et al.
Publicado: (2021)

Prolyl 3-Hydroxylase 2 Is a Molecular Player of Angiogenesis
por: Pignata, Paola, et al.
Publicado: (2021)

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor
por: Wang, Ruth X., et al.
Publicado: (2021)

Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification
por: Negri, Armando Luis
Publicado: (2022)

Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk
por: Harlow, Charli E, et al.
Publicado: (2022)

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors and Iron Metabolism
por: Ogawa, Chie, et al.
Publicado: (2023)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
por: Lun, Jie, et al.
Publicado: (2023)

Decreased expression of prolyl hydroxylase 1 is associated with poor prognosis in colorectal cancers
por: Melling, Nathaniel, et al.
Publicado: (2023)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor
por: Kiriakidis, Serafim, et al.
Publicado: (2017)

An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation
por: Zgraggen, Silvana, et al.
Publicado: (2014)

Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
por: Osmekhina, Ekaterina, et al.
Publicado: (2010)

Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle
por: Iwahashi, Masaaki, et al.
Publicado: (2012)

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
por: Durán, R V, et al.
Publicado: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
por: Chowdhury, Rasheduzzaman, et al.
Publicado: (2016)

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
por: Yeh, Tzu-Lan, et al.
Publicado: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
por: Savyuk, Maria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lb9f2bqn872diuoatl5fesghi8