Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that tau spreads through defined synaptic circuits, it is currently un...

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Detalles Bibliográficos
Autores principales: Pickett, Eleanor K., Henstridge, Christopher M., Allison, Elizabeth, Pitstick, Rose, Pooler, Amy, Wegmann, Susanne, Carlson, George, Hyman, Bradley T., Spires‐Jones, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516127/
https://www.ncbi.nlm.nih.gov/pubmed/28196395
http://dx.doi.org/10.1002/syn.21965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516127/
https://www.ncbi.nlm.nih.gov/pubmed/28196395
http://dx.doi.org/10.1002/syn.21965

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