Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

ARC‐520 Injection, an RNA interference drug for the treatment of hepatitis B that targets cccDNA‐derived viral mRNA transcripts with high specificity, effectively reduces the production of viral proteins and HBV DNA. In this phase 1 randomized, double‐blind, placebo‐controlled study, 54 healthy volu...

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Detalles Bibliográficos
Autores principales: Schluep, Thomas, Lickliter, Jason, Hamilton, James, Lewis, David L., Lai, Ching‐Lung, Lau, Johnson YN, Locarnini, Stephen A., Gish, Robert G., Given, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516171/
https://www.ncbi.nlm.nih.gov/pubmed/27739230
http://dx.doi.org/10.1002/cpdd.318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516171/
https://www.ncbi.nlm.nih.gov/pubmed/27739230
http://dx.doi.org/10.1002/cpdd.318

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