Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton translocation....

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Detalles Bibliográficos
Autores principales: Wang-Kan, Xuan, Blair, Jessica M. A., Chirullo, Barbara, Betts, Jonathan, La Ragione, Roberto M., Ivens, Alasdair, Ricci, Vito, Opperman, Timothy J., Piddock, Laura J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516257/
https://www.ncbi.nlm.nih.gov/pubmed/28720734
http://dx.doi.org/10.1128/mBio.00968-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516257/
https://www.ncbi.nlm.nih.gov/pubmed/28720734
http://dx.doi.org/10.1128/mBio.00968-17

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