A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity

Secondary metabolites are key mediators of virulence for many pathogens. Aspergillus fumigatus produces a vast array of these bioactive molecules, the biosynthesis of which is catalyzed by nonribosomal peptide synthetases (NRPSs) or polyketide synthases (PKSs). Both NRPSs and PKSs harbor carrier dom...

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Detalles Bibliográficos
Autores principales: Johns, Anna, Scharf, Daniel H., Gsaller, Fabio, Schmidt, Hella, Heinekamp, Thorsten, Straßburger, Maria, Oliver, Jason D., Birch, Mike, Beckmann, Nicola, Dobb, Katharine S., Gilsenan, Jane, Rash, Bharatkumar, Bignell, Elaine, Brakhage, Axel A., Bromley, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516258/
https://www.ncbi.nlm.nih.gov/pubmed/28720735
http://dx.doi.org/10.1128/mBio.01504-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516258/
https://www.ncbi.nlm.nih.gov/pubmed/28720735
http://dx.doi.org/10.1128/mBio.01504-16

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