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Determination of the optimal sample size for a clinical trial accounting for the population size

The problem of choosing a sample size for a clinical trial is a very common one. In some settings, such as rare diseases or other small populations, the large sample sizes usually associated with the standard frequentist approach may be infeasible, suggesting that the sample size chosen should refle...

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Detalles Bibliográficos
Autores principales: Stallard, Nigel, Miller, Frank, Day, Simon, Hee, Siew Wan, Madan, Jason, Zohar, Sarah, Posch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516263/
https://www.ncbi.nlm.nih.gov/pubmed/27184938
http://dx.doi.org/10.1002/bimj.201500228