Cargando…

Multiple-attempt dynamics of type IA topoisomerases revealed in an orthogonal single-molecule experiment

Topoisomerases are enzymes involved in maintaining the topological state of cellular DNA. Despite many structural, biophysical, and biochemical studies, their dynamic characteristics remain poorly understood. Recent single molecule experiments revealed that an important feature of the type IA topois...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gunn, Kathryn H., Marko, John F., Mondragón, Alfonso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516274/ https://www.ncbi.nlm.nih.gov/pubmed/28414321 http://dx.doi.org/10.1038/nsmb.3401

Ejemplares similares

Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways
por: Terekhova, Ksenia, et al.
Publicado: (2012)

Direct Observation of Topoisomerase IA Gate Dynamics
por: Mills, Maria, et al.
Publicado: (2018)

Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III
por: Terekhova, Ksenia, et al.
Publicado: (2014)

Mechanism of Type IA Topoisomerases
por: Dasgupta, Tumpa, et al.
Publicado: (2020)

Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States
por: Jeanne Dit Fouque, Kevin, et al.
Publicado: (2019)

Type IA Topoisomerases as Targets for Infectious Disease Treatments
por: Seddek, Ahmed, et al.
Publicado: (2021)

Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism
por: Osterman, Amy, et al.
Publicado: (2022)

Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens
por: Maurya, Vikas, et al.
Publicado: (2023)

Structural studies of type I topoisomerases
por: Baker, Nicole M., et al.
Publicado: (2009)

Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site
por: Rajan, Rakhi, et al.
Publicado: (2016)

Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)
por: Cheng, Bokun, et al.
Publicado: (2015)

Microbial Type IA Topoisomerase C-Terminal Domain Sequence Motifs, Distribution and Combination
por: Diaz, Brenda, et al.
Publicado: (2022)

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
por: Schmidt, Bryan H., et al.
Publicado: (2010)

Immunological dissection of human Ia molecules
Publicado: (1978)

A highly processive topoisomerase I: studies at the single-molecule level
por: Szafran, Marcin Jan, et al.
Publicado: (2014)

Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level
por: Proszek, Joanna, et al.
Publicado: (2014)

Multiple functional sites on a single Ia molecule defined using T cell clones and antibodies with chain-determined specificity
Publicado: (1984)

Unravelling the mechanisms of Type 1A topoisomerases using single-molecule approaches
por: Spakman, Dian, et al.
Publicado: (2021)

Identification of a Functional Type IA Topoisomerase, LdTopIIIβ, from Kinetoplastid Parasite Leishmania donovani
por: Banerjee, Bijoylaxmi, et al.
Publicado: (2011)

What’s on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases
por: Vidmar, Vita, et al.
Publicado: (2023)

Geländer Molecules with Orthogonal Joints: Synthesis of Macrocyclic Dimers
por: D'Addio, Adriano, et al.
Publicado: (2022)

The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV
por: Kokot, Maja, et al.
Publicado: (2022)

The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments
por: Ferdous, Shomita, et al.
Publicado: (2022)

Evidence for function of Ia molecules on gut epithelial cells in man
Publicado: (1987)

Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective
por: Collins, Tammy R. L., et al.
Publicado: (2009)

Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies
por: Rajan, Rakhi, et al.
Publicado: (2013)

The third orthogonal dynamic covalent bond
por: Lascano, Santiago, et al.
Publicado: (2016)

The role of Ia molecules in the activation of T lymphocytes. III. Antigen-specific, Ia-restricted, interleukin 2-producing T cell hybridomas with detectable affinity for the restricting I-A molecule
Publicado: (1983)

Binding of two DNA molecules by type II topoisomerases for decatenation
por: Kumar, Rupesh, et al.
Publicado: (2012)

Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases
por: Gu, Maxwell, et al.
Publicado: (2016)

Dynamic Divide Grouping Non-Orthogonal Multiple Access in Terrestrial-Satellite Integrated Network
por: Yan, Yanjun, et al.
Publicado: (2021)

Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis
Publicado: (1977)

Non-orthogonal multiple access for massive connectivity
por: Liu, Yuanwei, et al.
Publicado: (2019)

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor
por: Makasheva, Kristina, et al.
Publicado: (2021)

3IA Conference (3IA’2011)
por: Plemenos, Dimitri, et al.
Publicado: (2012)

Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web
por: Espenel, Cedric, et al.
Publicado: (2008)

Polymer architecture dictates multiple relaxation processes in soft networks with two orthogonal dynamic bonds
por: Ge, Sirui, et al.
Publicado: (2023)

Conformational Dynamics of DNA Polymerases Revealed at the Single-Molecule Level
por: Millar, David P.
Publicado: (2022)

Taguchi’s Orthogonal Arrays Are Classical Designs of Experiments
por: Kacker, Raghu N., et al.
Publicado: (1991)

Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
Publicado: (1979)

Cannot write session to /tmp/vufind_sessions/sess_cmru8uoam6mgftvad8lvn3ua8q