Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

The assembly process of α-synuclein toward amyloid fibers is linked to neurodegeneration in Parkinson’s disease. In the present study, we capitalized on the in vitro discovery of a small-molecule accelerator of α-synuclein amyloid formation and assessed its effects when injected in brains of normal...

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Detalles Bibliográficos
Autores principales: Chermenina, Maria, Chorell, Erik, Pokrzywa, Małgorzata, Antti, Henrik, Almqvist, Fredrik, Strömberg, Ingrid, Wittung-Stafshede, Pernilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516562/
https://www.ncbi.nlm.nih.gov/pubmed/28725689
http://dx.doi.org/10.1038/npjparkd.2015.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516562/
https://www.ncbi.nlm.nih.gov/pubmed/28725689
http://dx.doi.org/10.1038/npjparkd.2015.24

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