PD-1 blockade restores impaired function of ex vivo expanded CD8(+) T cells and enhances apoptosis in mismatch repair deficient EpCAM(+)PD-L1(+) cancer cells

BACKGROUND: Adoptive T cell therapy has been proven to be a promising modality for the treatment of cancer patients in recent years. However, the increased expression of inhibitory receptors could negatively regulate the function and persistence of transferred T cells which mediates T cell anergy, e...

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Detalles Bibliográficos
Autores principales: Kumar, Rajeev, Yu, Fang, Zhen, Yuan-Huan, Li, Bo, Wang, Jun, Yang, Yuan, Ge, Hui-Xin, Hu, Ping-Sheng, Xiu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516878/
https://www.ncbi.nlm.nih.gov/pubmed/28761354
http://dx.doi.org/10.2147/OTT.S130131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516878/
https://www.ncbi.nlm.nih.gov/pubmed/28761354
http://dx.doi.org/10.2147/OTT.S130131

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