Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells

Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into functional neurons. However, the protracted timing of human neuron specification and functional maturation remains a key challenge that hampers the routine application of hPSC-derived lineages in disease mode...

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Detalles Bibliográficos
Autores principales: Qi, Yuchen, Zhang, Xin-Jun, Renier, Nicolas, Wu, Zhuhao, Atkin, Talia, Sun, Ziyi, Ozair, M. Zeeshan, Tchieu, Jason, Zimmer, Bastian, Fattahi, Faranak, Ganat, Yosif, Azevedo, Ricardo, Zeltner, Nadja, Brivanlou, Ali H., Karayiorgou, Maria, Gogos, Joseph, Tomishima, Mark, Tessier-Lavigne, Marc, Shi, Song-Hai, Studer, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516899/
https://www.ncbi.nlm.nih.gov/pubmed/28112759
http://dx.doi.org/10.1038/nbt.3777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516899/
https://www.ncbi.nlm.nih.gov/pubmed/28112759
http://dx.doi.org/10.1038/nbt.3777

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