Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation

The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient...

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Detalles Bibliográficos
Autores principales: Kim, Eunhee, Sakata, Kazuko, Liao, Francesca-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517072/
https://www.ncbi.nlm.nih.gov/pubmed/28678786
http://dx.doi.org/10.1371/journal.pgen.1006849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517072/
https://www.ncbi.nlm.nih.gov/pubmed/28678786
http://dx.doi.org/10.1371/journal.pgen.1006849

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