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Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517072/ https://www.ncbi.nlm.nih.gov/pubmed/28678786 http://dx.doi.org/10.1371/journal.pgen.1006849 |