Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

TDP-43 pathology marks a spectrum of multisystem proteinopathies including amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and sporadic inclusion body myositis. Surprisingly, it has been challenging to recapitulate this pathology, highlighting an incomplete understanding of TDP-43...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Wander, Connor M., Yuan, Chao-Xing, Bereman, Michael S., Cohen, Todd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517419/
https://www.ncbi.nlm.nih.gov/pubmed/28724966
http://dx.doi.org/10.1038/s41467-017-00088-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517419/
https://www.ncbi.nlm.nih.gov/pubmed/28724966
http://dx.doi.org/10.1038/s41467-017-00088-4

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