An engineered protein antagonist of K-Ras/B-Raf interaction

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...

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Detalles Bibliográficos
Autores principales: Kauke, Monique J., Traxlmayr, Michael W., Parker, Jillian A., Kiefer, Jonathan D., Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517481/
https://www.ncbi.nlm.nih.gov/pubmed/28724936
http://dx.doi.org/10.1038/s41598-017-05889-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517481/
https://www.ncbi.nlm.nih.gov/pubmed/28724936
http://dx.doi.org/10.1038/s41598-017-05889-7

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