Cargando…

Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI

Spasticity, a common complication after spinal cord injury (SCI), is frequently accompanied by chronic pain. The physiological origin of this pain (critical to its treatment) remains unknown, although spastic motor dysfunction has been related to the hyperexcitability of motoneurons and to changes i...

Descripción completa

Detalles Bibliográficos
Autores principales: Kopach, Olga, Medvediev, Volodymyr, Krotov, Volodymyr, Borisyuk, Anya, Tsymbaliuk, Vitaliy, Voitenko, Nana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517549/
https://www.ncbi.nlm.nih.gov/pubmed/28724992
http://dx.doi.org/10.1038/s41598-017-06049-7
_version_ 1783251310511915008
author Kopach, Olga
Medvediev, Volodymyr
Krotov, Volodymyr
Borisyuk, Anya
Tsymbaliuk, Vitaliy
Voitenko, Nana
author_facet Kopach, Olga
Medvediev, Volodymyr
Krotov, Volodymyr
Borisyuk, Anya
Tsymbaliuk, Vitaliy
Voitenko, Nana
author_sort Kopach, Olga
collection PubMed
description Spasticity, a common complication after spinal cord injury (SCI), is frequently accompanied by chronic pain. The physiological origin of this pain (critical to its treatment) remains unknown, although spastic motor dysfunction has been related to the hyperexcitability of motoneurons and to changes in spinal sensory processing. Here we show that the pain mechanism involves changes in sensory circuits of the dorsal horn (DH) where nociceptive inputs integrate for pain processing. Spasticity is associated with the DH hyperexcitability resulting from an increase in excitation and disinhibition occurring in two respective types of sensory interneurons. In the tonic-firing inhibitory lamina II interneurons, glutamatergic drive was reduced while glycinergic inhibition was potentiated. In contrast, excitatory drive was boosted to the adapting-firing excitatory lamina II interneurons while GABAergic and glycinergic inhibition were reduced. Thus, increased activity of excitatory DH interneurons coupled with the reduced excitability of inhibitory DH interneurons post-SCI could provide a neurophysiological mechanism of central sensitization and chronic pain associated with spasticity.
format Online
Article
Text
id pubmed-5517549
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55175492017-07-20 Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI Kopach, Olga Medvediev, Volodymyr Krotov, Volodymyr Borisyuk, Anya Tsymbaliuk, Vitaliy Voitenko, Nana Sci Rep Article Spasticity, a common complication after spinal cord injury (SCI), is frequently accompanied by chronic pain. The physiological origin of this pain (critical to its treatment) remains unknown, although spastic motor dysfunction has been related to the hyperexcitability of motoneurons and to changes in spinal sensory processing. Here we show that the pain mechanism involves changes in sensory circuits of the dorsal horn (DH) where nociceptive inputs integrate for pain processing. Spasticity is associated with the DH hyperexcitability resulting from an increase in excitation and disinhibition occurring in two respective types of sensory interneurons. In the tonic-firing inhibitory lamina II interneurons, glutamatergic drive was reduced while glycinergic inhibition was potentiated. In contrast, excitatory drive was boosted to the adapting-firing excitatory lamina II interneurons while GABAergic and glycinergic inhibition were reduced. Thus, increased activity of excitatory DH interneurons coupled with the reduced excitability of inhibitory DH interneurons post-SCI could provide a neurophysiological mechanism of central sensitization and chronic pain associated with spasticity. Nature Publishing Group UK 2017-07-19 /pmc/articles/PMC5517549/ /pubmed/28724992 http://dx.doi.org/10.1038/s41598-017-06049-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kopach, Olga
Medvediev, Volodymyr
Krotov, Volodymyr
Borisyuk, Anya
Tsymbaliuk, Vitaliy
Voitenko, Nana
Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title_full Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title_fullStr Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title_full_unstemmed Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title_short Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
title_sort opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-sci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517549/
https://www.ncbi.nlm.nih.gov/pubmed/28724992
http://dx.doi.org/10.1038/s41598-017-06049-7
work_keys_str_mv AT kopacholga oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci
AT medvedievvolodymyr oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci
AT krotovvolodymyr oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci
AT borisyukanya oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci
AT tsymbaliukvitaliy oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci
AT voitenkonana oppositebidirectionalshiftsinexcitationandinhibitioninspecifictypesofdorsalhorninterneuronsareassociatedwithspasticityandpainpostsci