Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunits p110γ and p110δ of PI3Kγ and PI3Kδ in p110γ/δ(−/−) mice leads to defective B-...

Descripción completa

Detalles Bibliográficos
Autores principales: Bucher, Kirsten, Schmitt, Fee, Mothes, Benedikt, Blumendeller, Carolin, Schäll, Daniel, Piekorz, Roland, Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518148/
https://www.ncbi.nlm.nih.gov/pubmed/28724384
http://dx.doi.org/10.1186/s12964-017-0185-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518148/
https://www.ncbi.nlm.nih.gov/pubmed/28724384
http://dx.doi.org/10.1186/s12964-017-0185-y

Ejemplares similares