Cargando…

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunits p110γ and p110δ of PI3Kγ and PI3Kδ in p110γ/δ(−/−) mice leads to defective B-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bucher, Kirsten, Schmitt, Fee, Mothes, Benedikt, Blumendeller, Carolin, Schäll, Daniel, Piekorz, Roland, Hirsch, Emilio, Nürnberg, Bernd, Beer-Hammer, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518148/ https://www.ncbi.nlm.nih.gov/pubmed/28724384 http://dx.doi.org/10.1186/s12964-017-0185-y

Ejemplares similares

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation
por: Mothes, Benedikt, et al.
Publicado: (2016)

Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation
por: Mothes, Benedikt, et al.
Publicado: (2016)

Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
por: Okkenhaug, Klaus, et al.
Publicado: (2007)

Deficiency of p110δ Isoform of the Phosphoinositide 3 Kinase Leads to Enhanced Resistance to Leishmania donovani
por: Khadem, Forough, et al.
Publicado: (2014)

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
por: Hassenrück, Floyd, et al.
Publicado: (2023)

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function
por: Moore, Samantha F., et al.
Publicado: (2019)

Regulation of p110δ PI 3-Kinase Gene Expression
por: Kok, Klaartje, et al.
Publicado: (2009)

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α
por: Burke, John E., et al.
Publicado: (2011)

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
por: Berenjeno, Inma M., et al.
Publicado: (2012)

p110δ PI3 kinase pathway: emerging roles in cancer
por: Tzenaki, Niki, et al.
Publicado: (2013)

Phosphatidylinositol 3-kinase p110δ expression in Merkel cell carcinoma
por: Chteinberg, Emil, et al.
Publicado: (2018)

The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
por: Ivison, Sabine M., et al.
Publicado: (2010)

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
por: Al-Qassab, Hind, et al.
Publicado: (2009)

Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
por: Mazloumi Gavgani, Fatemeh, et al.
Publicado: (2018)

Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure
por: Jia, Wenqing, et al.
Publicado: (2022)

Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase
por: Eickholt, Britta J., et al.
Publicado: (2007)

The PI3K p110δ Regulates Expression of CD38 on Regulatory T Cells
por: Patton, Daniel T., et al.
Publicado: (2011)

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
por: Soler, Adriana, et al.
Publicado: (2013)

Conduction-band states in GaSb(110) and GaP(110) at the Brillouin-zone center
por: Faul, J, et al.
Publicado: (1993)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
por: Zhang, Lei, et al.
Publicado: (2020)

Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth
por: Zhou, Yubing, et al.
Publicado: (2015)

Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling
por: Zhang, Biqin, et al.
Publicado: (2021)

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter
por: Whitehead, Maria A., et al.
Publicado: (2012)

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
por: Clayton, Elizabeth, et al.
Publicado: (2002)

The p110δ crystal structure uncovers mechanisms for selectivity and potency of novel PI3K inhibitors
por: Berndt, Alex, et al.
Publicado: (2010)

Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase P110δ Prevents Chronic Rejection of Heart Allografts
por: Ying, Huijun, et al.
Publicado: (2012)

Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer
por: Ali, Khaled, et al.
Publicado: (2014)

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation
por: Doisne, Jean-Marc, et al.
Publicado: (2015)

Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury
por: Bilancio, Antonio, et al.
Publicado: (2017)

PI3Kinase-p110δ Overexpression Impairs Dendritic Morphogenesis and Increases Dendritic Spine Density
por: Hood, Veronica L., et al.
Publicado: (2020)

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity
por: Buchanan, Christina M., et al.
Publicado: (2013)

Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex
por: Müller, Rabea, et al.
Publicado: (2013)

Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase
por: Dbouk, Hashem A., et al.
Publicado: (2013)

Puquitinib mesylate, an inhibitor of phosphatidylinositol 3-kinase p110δ, for treating relapsed or refractory non-Hodgkin's lymphoma
por: Yang, Hang, et al.
Publicado: (2015)

Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils
por: Manda-Handzlik, Aneta, et al.
Publicado: (2022)

Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
por: Brock, Carsten, et al.
Publicado: (2003)

Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
por: Jeong, Ju-yeon, et al.
Publicado: (2013)

Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas
por: Fransson, Susanne, et al.
Publicado: (2013)

PTEN regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression
por: Miller, Karina, et al.
Publicado: (2023)

Letter of intent: study of $\overline{p}p$ interactions with the R-110 detector
por: Besch, H J, et al.
Publicado: (1980)

Cannot write session to /tmp/vufind_sessions/sess_rp4v7orpkmh7f5pfpa07t87gvc