In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat models

The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vaginal application with nonoxinol-9 as the model drug. Two in situ hydrogel formulations, which contained 18% poloxamer 407 plus 1% poloxamer 188 (GEL1, relative hydrophobic) or 6% p...

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Detalles Bibliográficos
Autores principales: Liu, Yu, Yang, Fujin, Feng, Linglin, Yang, Long, Chen, Lingyun, Wei, Gang, Lu, Weiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518644/
https://www.ncbi.nlm.nih.gov/pubmed/28752037
http://dx.doi.org/10.1016/j.apsb.2017.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518644/
https://www.ncbi.nlm.nih.gov/pubmed/28752037
http://dx.doi.org/10.1016/j.apsb.2017.03.003

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