Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets

OBJECTIVES: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP), contributes to islet inflammation and β-cell d...

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Detalles Bibliográficos
Autores principales: Hui, Queenie, Asadi, Ali, Park, Yoo Jin, Kieffer, Timothy J., Ao, Ziliang, Warnock, Garth L., Marzban, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518725/
https://www.ncbi.nlm.nih.gov/pubmed/28752047
http://dx.doi.org/10.1016/j.molmet.2017.05.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518725/
https://www.ncbi.nlm.nih.gov/pubmed/28752047
http://dx.doi.org/10.1016/j.molmet.2017.05.016

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