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Polymorphisms associated with everolimus pharmacokinetics, toxicity and survival in metastatic breast cancer
PURPOSE: Metastatic breast cancer (MBC) progressing after endocrine therapy frequently activates PI3K/AKT/mTOR pathway. The BOLERO-2 trial showed that everolimus-exemestane achieves increased progression free survival (PFS) compared with exemestane. However, there is great inter-patient variability...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519037/ https://www.ncbi.nlm.nih.gov/pubmed/28727815 http://dx.doi.org/10.1371/journal.pone.0180192 |