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Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy
BACKGROUND: In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortalit...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519044/ https://www.ncbi.nlm.nih.gov/pubmed/28727746 http://dx.doi.org/10.1371/journal.pone.0180103 |