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Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy

BACKGROUND: In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortalit...

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Detalles Bibliográficos
Autores principales: Carillion, Aude, Feldman, Sarah, Na, Na, Biais, Matthieu, Carpentier, Wassila, Birenbaum, Aurélie, Cagnard, Nicolas, Loyer, Xavier, Bonnefont-Rousselot, Dominique, Hatem, Stéphane, Riou, Bruno, Amour, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519044/
https://www.ncbi.nlm.nih.gov/pubmed/28727746
http://dx.doi.org/10.1371/journal.pone.0180103