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Atomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations

The mitochondrial ADP/ATP carrier (AAC) is a membrane transporter that exchanges a cytosolic ADP for a matrix ATP. Atomic structures in an outward-facing (OF) form which binds an ADP from the intermembrane space have been solved by X-ray crystallography, and revealed their unique pseudo three-fold s...

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Detalles Bibliográficos
Autores principales: Tamura, Koichi, Hayashi, Shigehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519185/
https://www.ncbi.nlm.nih.gov/pubmed/28727843
http://dx.doi.org/10.1371/journal.pone.0181489