MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells

Mixed-lineage kinase 3 (MLK3), a mitogen-activated protein kinase kinase kinase (MAP3K), has critical roles in metastasis of triple-negative breast cancer (TNBC), in part by regulating paxillin phosphorylation and focal adhesion turnover. However the mechanisms and the distinct step(s) of the metast...

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Detalles Bibliográficos
Autores principales: Rattanasinchai, C, Llewellyn, B J, Conrad, S E, Gallo, K A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519193/
https://www.ncbi.nlm.nih.gov/pubmed/28604765
http://dx.doi.org/10.1038/oncsis.2017.44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519193/
https://www.ncbi.nlm.nih.gov/pubmed/28604765
http://dx.doi.org/10.1038/oncsis.2017.44

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