Cargando…

MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells

Mixed-lineage kinase 3 (MLK3), a mitogen-activated protein kinase kinase kinase (MAP3K), has critical roles in metastasis of triple-negative breast cancer (TNBC), in part by regulating paxillin phosphorylation and focal adhesion turnover. However the mechanisms and the distinct step(s) of the metast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rattanasinchai, C, Llewellyn, B J, Conrad, S E, Gallo, K A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519193/ https://www.ncbi.nlm.nih.gov/pubmed/28604765 http://dx.doi.org/10.1038/oncsis.2017.44

Ejemplares similares

MLK3 Signaling in Cancer Invasion
por: Rattanasinchai, Chotirat, et al.
Publicado: (2016)

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance
por: Mehlich, Dawid, et al.
Publicado: (2021)

Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer
por: Zhang, Cong, et al.
Publicado: (2021)

MLK4β functions as a negative regulator of MAPK signaling and cell invasion
por: Abi Saab, W F, et al.
Publicado: (2012)

Cloning and Initial Functional Characterization of Mlk4α and Mlk4β
por: Kashuba, Vladimir I, et al.
Publicado: (2011)

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells
por: Marusiak, Anna A., et al.
Publicado: (2018)

Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells
por: Koudelkova, Petra, et al.
Publicado: (2017)

GROα overexpression drives cell migration and invasion in triple negative breast cancer cells
por: Bhat, Kruttika, et al.
Publicado: (2017)

VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma
por: Chen, Li, et al.
Publicado: (2020)

Leflunomide leads to inhibition of transendothelial migration
por: Grisar, J, et al.
Publicado: (2001)

TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation
por: Sondarva, Gautam, et al.
Publicado: (2009)

L-selectin regulates human neutrophil transendothelial migration
por: Rahman, Izajur, et al.
Publicado: (2021)

PECAM-1 is required for transendothelial migration of leukocytes
Publicado: (1993)

Enhanced transendothelial in vitro migration of scleroderma lymphocytes
por: Stummvoll, GH, et al.
Publicado: (2001)

Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease
por: O’Shannessy, Daniel J, et al.
Publicado: (2012)

To FRA or not to FRA: What is the question for science education?
por: Dagher, Zoubeida R., et al.
Publicado: (2023)

Leukotriene B(4)-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
por: Colom, Bartomeu, et al.
Publicado: (2015)

LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration
por: Liu, Lixin, et al.
Publicado: (2005)

Phenotypic characteristics of human monocytes undergoing transendothelial migration
por: Grisar, Johannes, et al.
Publicado: (2001)

Elucidating the Biomechanics of Leukocyte Transendothelial Migration by Quantitative Imaging
por: Schwartz, Amy B., et al.
Publicado: (2021)

In vitro Studies of Transendothelial Migration for Biological and Drug Discovery
por: Salminen, Alec T., et al.
Publicado: (2020)

A novel neuregulin – jagged1 paracrine loop in breast cancer transendothelial migration
por: Cabrera, Ramon M., et al.
Publicado: (2018)

Methylene Blue Modulates Transendothelial Migration of Peripheral Blood Cells
por: Werner, Isabella, et al.
Publicado: (2013)

An agent-based model of leukocyte transendothelial migration during atherogenesis
por: Bhui, Rita, et al.
Publicado: (2017)

Rho GTPase signalling networks in cancer cell transendothelial migration
por: Rodenburg, Wessel S, et al.
Publicado: (2021)

Efficient Transendothelial Migration of Latently HIV-1-Infected Cells
por: Tanabe, Reou, et al.
Publicado: (2021)

FRA 2005
Publicado: (2007)

Fra Angelico /
por: Angelico, fra, ca. 1400-1455
Publicado: (1992)

Signal Regulatory Protein α Negatively Regulates β(2) Integrin-Mediated Monocyte Adhesion, Transendothelial Migration and Phagocytosis
por: Liu, Dan-Qing, et al.
Publicado: (2008)

Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs
por: Niu, Weipin, et al.
Publicado: (2020)

The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells
por: Maddaluno, Luigi, et al.
Publicado: (2009)

Regulation of endothelial permeability and transendothelial migration of cancer cells by tropomyosin-1 phosphorylation
por: Simoneau, Bryan, et al.
Publicado: (2012)

Endothelial Cell Focal Adhesion Regulates Transendothelial Migration and Subendothelial Crawling of T Cells
por: Lee, Jaehyun, et al.
Publicado: (2018)

PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration
por: Piao, Wenji, et al.
Publicado: (2022)

VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
por: Zhang, Dan, et al.
Publicado: (2020)

Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers
por: Bejjani, Fabienne, et al.
Publicado: (2021)

MLK3 Phophorylates AMPK Independently of LKB1
por: Luo, Lingyu, et al.
Publicado: (2015)

Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration
por: Wang, Weiyu, et al.
Publicado: (2022)

MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis
por: Dutta, Pranabananda, et al.
Publicado: (2018)

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer
por: Tan, Zheqiong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7osfucu2se7grdbmjub02a57al