TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Microglia coordinate various functions in the central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, and clearing protein aggregates across the lifespan. Here we investigated whether increased microglial phagocytic activit...

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Detalles Bibliográficos
Autores principales: Paolicelli, Rosa C., Jawaid, Ali, Henstridge, Christopher M., Valeri, Andrea, Merlini, Mario, Robinson, John L., Lee, Edward B., Rose, Jamie, Appel, Stanley, Lee, Virginia M.-Y., Trojanowski, John Q., Spires-Jones, Tara, Schulz, Paul E., Rajendran, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519492/
https://www.ncbi.nlm.nih.gov/pubmed/28669544
http://dx.doi.org/10.1016/j.neuron.2017.05.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519492/
https://www.ncbi.nlm.nih.gov/pubmed/28669544
http://dx.doi.org/10.1016/j.neuron.2017.05.037

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