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Cell Death-Autophagy Loop and Glutamate-Glutamine Cycle in Amyotrophic Lateral Sclerosis

Although we know that amyotrophic lateral sclerosis (ALS) is correlated with the glutamate-mediated corticomotor neuronal hyperexcitability, detailed ALS pathology remains largely unexplained. While a number of drugs have been developed, no cure exists so far. Here, we propose a hypothesis of neuron...

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Detalles Bibliográficos
Autores principales: Yuan, Shu, Zhang, Zhong-Wei, Li, Zi-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519524/
https://www.ncbi.nlm.nih.gov/pubmed/28785203
http://dx.doi.org/10.3389/fnmol.2017.00231