Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence

Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms. Therefore, the inhibition of GtfBCD would provide anti-virulence therapeutics. Here a small molecule library of 500,000 small molecule compounds was screened in silico ag...

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Detalles Bibliográficos
Autores principales: Zhang, Qiong, Nijampatnam, Bhavitavya, Hua, Zhang, Nguyen, Thao, Zou, Jing, Cai, Xia, Michalek, Suzanne M., Velu, Sadanandan E., Wu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519559/
https://www.ncbi.nlm.nih.gov/pubmed/28729722
http://dx.doi.org/10.1038/s41598-017-06168-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519559/
https://www.ncbi.nlm.nih.gov/pubmed/28729722
http://dx.doi.org/10.1038/s41598-017-06168-1

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