A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

Huntington’s disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology b...

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Detalles Bibliográficos
Autores principales: Suelves, Nuria, Kirkham-McCarthy, Lucy, Lahue, Robert S., Ginés, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519595/
https://www.ncbi.nlm.nih.gov/pubmed/28729730
http://dx.doi.org/10.1038/s41598-017-05125-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519595/
https://www.ncbi.nlm.nih.gov/pubmed/28729730
http://dx.doi.org/10.1038/s41598-017-05125-2

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