Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes

dUTPase superfamily enzymes generate dUMP, the obligate precursor for de novo dTTP biosynthesis, from either dUTP (monofunctional dUTPase, Dut) or dCTP (bifunctional dCTP deaminase/dUTPase, Dcd:dut). In addition, the elimination of dUTP by these enzymes prevents harmful uracil incorporation into DNA...

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Detalles Bibliográficos
Autores principales: Hirmondo, Rita, Lopata, Anna, Suranyi, Eva Viola, Vertessy, Beata G., Toth, Judit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519681/
https://www.ncbi.nlm.nih.gov/pubmed/28729658
http://dx.doi.org/10.1038/s41598-017-06206-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519681/
https://www.ncbi.nlm.nih.gov/pubmed/28729658
http://dx.doi.org/10.1038/s41598-017-06206-y

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