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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography
Continuous‐flow multistep synthesis is combined with quasi‐continuous final‐product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4‐difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desir...
Autores principales: | Örkényi, Róbert, Éles, János, Faigl, Ferenc, Vincze, Péter, Prechl, Anita, Szakács, Zoltán, Kóti, János, Greiner, István |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519935/ https://www.ncbi.nlm.nih.gov/pubmed/28548374 http://dx.doi.org/10.1002/anie.201703852 |
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