Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These antigens are absent from the current tuberculosis vaccine, BCG. Here we compare the protection induced by BCG and MTBVAC in several mouse stra...

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Detalles Bibliográficos
Autores principales: Aguilo, Nacho, Gonzalo-Asensio, Jesus, Alvarez-Arguedas, Samuel, Marinova, Dessislava, Gomez, Ana Belen, Uranga, Santiago, Spallek, Ralf, Singh, Mahavir, Audran, Regine, Spertini, François, Martin, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519979/
https://www.ncbi.nlm.nih.gov/pubmed/28706226
http://dx.doi.org/10.1038/ncomms16085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519979/
https://www.ncbi.nlm.nih.gov/pubmed/28706226
http://dx.doi.org/10.1038/ncomms16085

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