MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2 deficiency. The nucleolytic activity of MUS81 endonuclease is required for replication fork restart under replication stress elicited by exogenous...

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Detalles Bibliográficos
Autores principales: Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520020/
https://www.ncbi.nlm.nih.gov/pubmed/28714477
http://dx.doi.org/10.1038/ncomms15983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520020/
https://www.ncbi.nlm.nih.gov/pubmed/28714477
http://dx.doi.org/10.1038/ncomms15983

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