Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a ‘piggy-back’ strategy in which peptides bind via a ligan...

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Detalles Bibliográficos
Autores principales: Zorzi, Alessandro, Middendorp, Simon J., Wilbs, Jonas, Deyle, Kaycie, Heinis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520048/
https://www.ncbi.nlm.nih.gov/pubmed/28714475
http://dx.doi.org/10.1038/ncomms16092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520048/
https://www.ncbi.nlm.nih.gov/pubmed/28714475
http://dx.doi.org/10.1038/ncomms16092

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