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Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
Precise spatiotemporal gene regulation is paramount for the establishment and maintenance of cell-specific programmes. Although there is evidence that chromatin neighbourhoods, formed by the zinc-finger protein CTCF, can sequester enhancers and their target genes, there is limited in vivo evidence f...
Autores principales: | Willi, M., Yoo, K. H., Reinisch, F., Kuhns, T. M., Lee, H. K., Wang, C., Hennighausen, L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520053/ https://www.ncbi.nlm.nih.gov/pubmed/28714474 http://dx.doi.org/10.1038/ncomms16069 |
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