Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Hematopoietic stem cells (HSCs) are maintained in a hypoxic niche to limit oxidative stress. Although iron elicits oxidative stress, the importance of iron homeostasis in HSCs has been unknown. Here we show that iron regulation by the F-box protein FBXL5 is required for HSC self-renewal. Conditional...

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Detalles Bibliográficos
Autores principales: Muto, Yoshiharu, Nishiyama, Masaaki, Nita, Akihiro, Moroishi, Toshiro, Nakayama, Keiichi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520054/
https://www.ncbi.nlm.nih.gov/pubmed/28714470
http://dx.doi.org/10.1038/ncomms16114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520054/
https://www.ncbi.nlm.nih.gov/pubmed/28714470
http://dx.doi.org/10.1038/ncomms16114

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