Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation reference panels accurately predict genotypes for common variants with minor allele frequency (MAF)≥5% and low-frequency variants (0.5≤MAF&l...

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Detalles Bibliográficos
Autores principales: Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520064/
https://www.ncbi.nlm.nih.gov/pubmed/28401899
http://dx.doi.org/10.1038/ejhg.2017.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520064/
https://www.ncbi.nlm.nih.gov/pubmed/28401899
http://dx.doi.org/10.1038/ejhg.2017.51

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