De novo active sites for resurrected Precambrian enzymes

Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed many different reactions already in the last universal common ancestor. Mechanisms for the emergence of completely new active sites must therefo...

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Detalles Bibliográficos
Autores principales: Risso, Valeria A., Martinez-Rodriguez, Sergio, Candel, Adela M., Krüger, Dennis M., Pantoja-Uceda, David, Ortega-Muñoz, Mariano, Santoyo-Gonzalez, Francisco, Gaucher, Eric A., Kamerlin, Shina C. L., Bruix, Marta, Gavira, Jose A., Sanchez-Ruiz, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520109/
https://www.ncbi.nlm.nih.gov/pubmed/28719578
http://dx.doi.org/10.1038/ncomms16113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520109/
https://www.ncbi.nlm.nih.gov/pubmed/28719578
http://dx.doi.org/10.1038/ncomms16113

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