Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

BACKGROUND: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern of localised hypermutation. We assessed the cellular phenotypes associated with high-level APOBEC3B expression and the influence of p53 status on these phenotypes using an isogenic system. METHODS: We used RNA int...

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Detalles Bibliográficos
Autores principales: Nikkilä, Jenni, Kumar, Rahul, Campbell, James, Brandsma, Inger, Pemberton, Helen N, Wallberg, Fredrik, Nagy, Kinga, Scheer, Ildikó, Vertessy, Beata G, Serebrenik, Artur A, Monni, Valentina, Harris, Reuben S, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520199/
https://www.ncbi.nlm.nih.gov/pubmed/28535155
http://dx.doi.org/10.1038/bjc.2017.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520199/
https://www.ncbi.nlm.nih.gov/pubmed/28535155
http://dx.doi.org/10.1038/bjc.2017.133

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