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Implementing the EffTox dose-finding design in the Matchpoint trial

BACKGROUND: The Matchpoint trial aims to identify the optimal dose of ponatinib to give with conventional chemotherapy consisting of fludarabine, cytarabine and idarubicin to chronic myeloid leukaemia patients in blastic transformation phase. The dose should be both tolerable and efficacious. This p...

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Detalles Bibliográficos
Autores principales: Brock, Kristian, Billingham, Lucinda, Copland, Mhairi, Siddique, Shamyla, Sirovica, Mirjana, Yap, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520236/
https://www.ncbi.nlm.nih.gov/pubmed/28728594
http://dx.doi.org/10.1186/s12874-017-0381-x