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Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA

The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue. The serum and liver biopsy samples were coll...

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Detalles Bibliográficos
Autores principales: Rybicka, Magda, Woziwodzka, Anna, Romanowski, Tomasz, Stalke, Piotr, Dręczewski, Marcin, Bielawski, Krzysztof Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520316/
https://www.ncbi.nlm.nih.gov/pubmed/28634352
http://dx.doi.org/10.1038/emi.2017.41