Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner

Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer effects by causing damage to cellular DNA. However, systemic treatment damages DNA not only in cancer, but also in healthy cells, resulting in the progression of serious side effects and limiting efficacy of the...

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Detalles Bibliográficos
Autores principales: Wamsley, J J, Gary, C, Biktasova, A, Hajek, M, Bellinger, G, Virk, R, Issaeva, N, Yarbrough, W G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520489/
https://www.ncbi.nlm.nih.gov/pubmed/28394357
http://dx.doi.org/10.1038/oncsis.2017.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520489/
https://www.ncbi.nlm.nih.gov/pubmed/28394357
http://dx.doi.org/10.1038/oncsis.2017.12

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